Roy Billing Peter Parker / Spider-Man Thomas Gibson MJ Elizabeth Hanks Doctor Strange Goparaju Ramana Ned Leeds Thomas Mathew Max Dillon / Electro Manisha Koirala Norman Osborn / Green Goblin Natsuki Hanae Dr. Otto Octavius / Doc Ock Cole Sprouse Dr. Curt Connors / The Lizard Ken Watanabe Flint Marko / Sandman Erica Beck Peter Parker / Spider-Man Annie Parisse Peter Parker / Spider-Man Feroz Khan Happy Hogan P.J. Byrne Wong Mark O'Brien Flash Thompson Claire Geare May Parker Yuji Okumoto Betty Brant Patrick Fischler Agent Cleary Moisés Arias MIT Assistant Vice Chancellor Liev Schreiber Coach Wilson Daisy Lightfoot Mr. Harrington Earl Cameron Mr. Dell Jung Jin-woo J. Jonah Jameson Kimberly Hébert Gregory Matt Murdock Parminder Nagra Apprentice Claire Forlani Arena Bystander Cynthia Evans Arena Bystander Gary Weeks Arena Bystander Sophia Bernard Mom in Car Emily Baldoni Kid in Car Rebecca Chulew Kid in Car Sue-Lynn Ansari Man in Car Gintare Beinoraviciute Agent Foster Cecilia Leal Donut Shop Boss Brett Austin Johnson Donut Shop Waitress Evangeline Hill School Security Guard Mélanie Laurent Reporter Nithish Veera Eddie Brock / Venom (uncredited) Geoff Bell Self Sofia Boutella Self Michael Caine Self Sophie Cookson Self Jack Davenport Self Taron Egerton Self Colin Firth Self Dave Gibbons Self Jane Goldman Self Mark Hamill Self Eddie Hamilton Self Samuel L. Jackson Self Jordan Long Self Mark Millar Self Arianne Phillips Self Mark Strong Self Matthew Vaughn Self Damien Walters Self